2026 ISSVD update terminology for Vulvar Intraepithelial Neoplasia and Squamous Intraepithelial Lesions
Why This Update Matters Over the last several years, advances in pathology, molecular diagnostics, and our understanding of HPV-associated and HPV-independent disease pathways have revealed the need for a more consistent and biologically meaningful classification system. The new ISSVD terminology: Classifies disease according to HPV-associated (HPVa) and HPV-independent (HPVi) pathways Establishes p16 and p53 immunohistochemistry …